Abstract
This study was designed to determine the effects of an aluminum hydroxide antacid and a calcium carbonate antacid on the bioavailability of ciprofloxacin (Cipro). Cipro (750 mg) was administered orally to 12 healthy volunteers in a three-way randomized crossover design. The three treatments included Cipro alone, four 850-mg calcium carbonate tablets taken 5 min before Cipro, and three 600-mg aluminum hydroxide tablets taken 5 min before Cipro. The relative bioavailability of Cipro when given with calcium carbonate was approximately 60% of the control value. When Cipro was given with aluminum hydroxide, the relative bioavailability was approximately 15%. Urinary recovery of Cipro in the aluminum hydroxide treatment group was approximately one-fourth of that in the calcium carbonate group. Although calcium carbonate decreased absorption to a lesser extent than aluminum hydroxide, these data suggest that antacids containing either aluminum or calcium should not be given concomitantly with Cipro.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Auckenthaler R., Michéa-Hamzehpour M., Pechère J. C. In-vitro activity of newer quinolones against aerobic bacteria. J Antimicrob Chemother. 1986 Apr;17 (Suppl B):29–39. doi: 10.1093/jac/17.suppl_b.29. [DOI] [PubMed] [Google Scholar]
- Fleming L. W., Moreland T. A., Stewart W. K., Scott A. C. Ciprofloxacin and antacids. Lancet. 1986 Aug 2;2(8501):294–294. doi: 10.1016/s0140-6736(86)92120-3. [DOI] [PubMed] [Google Scholar]
- Frost R. W., Carlson J. D., Dietz A. J., Jr, Heyd A., Lettieri J. T. Ciprofloxacin pharmacokinetics after a standard or high-fat/high-calcium breakfast. J Clin Pharmacol. 1989 Oct;29(10):953–955. doi: 10.1002/j.1552-4604.1989.tb03260.x. [DOI] [PubMed] [Google Scholar]
- Golper T. A., Hartstein A. I., Morthland V. H., Christensen J. M. Effects of antacids and dialysate dwell times on multiple-dose pharmacokinetics of oral ciprofloxacin in patients on continuous ambulatory peritoneal dialysis. Antimicrob Agents Chemother. 1987 Nov;31(11):1787–1790. doi: 10.1128/aac.31.11.1787. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nix D. E., Watson W. A., Lener M. E., Frost R. W., Krol G., Goldstein H., Lettieri J., Schentag J. J. Effects of aluminum and magnesium antacids and ranitidine on the absorption of ciprofloxacin. Clin Pharmacol Ther. 1989 Dec;46(6):700–705. doi: 10.1038/clpt.1989.207. [DOI] [PubMed] [Google Scholar]