Table 2(A).
Changes in Serum and Cellular Cytokine levels over 24 weeks of IFN-beta qw (n=8)
| pg/ml mean±SE | Pre-Rx mean | 4 weeks | 8 Weeks | 12 weeks | 16 Weeks | 20 weeks | 24 weeks | Post-Rx mean |
|---|---|---|---|---|---|---|---|---|
| Serum IL10 | 13.36±1.31 | 13.49±1.17 | 13.45±1.43 | 13.57±1.73 | 14.21±2.00 | 12.27±1.02 | 12.51±0.71 | 13.05±0.56 |
| Serum IL12p70 | 53.71±8.36 | 56.80±4.57 | 50.77±6.19 | 45.22±7.69 | 46.93±9.43 | 41.52±5.67 | 47.89±5.77 | 48.19±2.69* |
| Serum 10/12p70 | 0.253 ± 0.023 | 0.228 ± 0.0274 | 0.288 ± 0.044 | 0.329 ± 0.039 | 0.330 ± 0.035 | 0.318 ± 0.027 | 0.287 ± 0.035 | 0.297±0.014 |
| cellular IL10 | 424.8±125.5 | 330.3±59.06 | 336.2±100.4 | 1062±351.0 | 758.8±225.0 | 1249±553.7 | 547.6±111.7 | 713.9±123.1† |
| cellular IL12p40 | 1299±282.3 | 1266±450.3 | 1120±384.6 | 1381±321.6 | 1164±215.7 | 811.1±179.5 | 1028±177.6 | 1128±121.2 |
| cellular IL12p70 | 63.77±22.89 | 72.10±28.10 | 23.86±12.14 | 108.1±56.86 | 55.29±15.90 | 62.33±26.16 | 21.99±4.457 | 57.27±12.07 |
| cellular IFN-g | 845.8±261.2 | 417.1±307.0 | 239.2±97.97 | 221.4±54.02 | 194.5±67.42 | 299.5±104.4 | 341.2±154.0 | 285.5±61.21 |
†=value significantly different vs. pre-treatment (p<0.05 by repeated measures ANOVA)
*=value significantly different vs tiw (p<0.05 by Mann-Whitney)