Table 2(B).
Changes in Serum and Cellular Cytokine levels over 24 weeks of IFN-beta tiw (n=7)
| pg/ml mean±SE | Pre-Rx mean | 4 weeks | 8 weeks | 12 weeks | 16 weeks | 20 weeks | 24 weeks | Post-Rx mean |
|---|---|---|---|---|---|---|---|---|
| Serum IL10 | 15.14±1.08 | 14.40±0.84 | 13.55±1.45 | 15.73±1.56 | 14.72±1.39 | 13.91±1.16 | 14.19±1.61 | 14.42±0.53 |
| Serum IL12p70 | 76.15±9.05 | 80.75±15.48 | 88.92±15.60 | 75.71±10.41 | 70.62±13.11 | 64.17±13.78 | 73.31±13.62 | 75.58±5.41* |
| Serum 10/12p70 | 0.208 ± 0.027 | 0.217 ± 0.038 | 0.178 ± 0.030 | 0.220 ± 0.021 | 0.260 ± 0.047 | 0.276 ± 0.063 | 0.235 ± 0.050 | 0.231±0.017 |
| cellular IL10 | 360.7±121.8 | 427.6±220.1 | 412.8±155.0 | 725.5±149.7 | 1499±600.2 | 1246±594.4 | 1648±992.3 | 993.1±223.0 |
| cellular IL12p40 | 2146±548.1 | 1602±282.6 | 1168±308.1 | 2125±508.1 | 1753±345.9 | 1635±317.8 | 1033±136.5 | 1578±141.3 |
| cellular IL12p70 | 75.21±20.85 | 84.84±26.67 | 106.9±40.22 | 247.3±76.49 | 214.7±89.97 | 102.5±29.26 | 81.64±23.72 | 139.7±23.18† |
| cellular IFN-g | 755.7±222.3 | 451.9±131.4 | 244.8±111.7 | 482.2±214.0 | 341.8±127.7 | 434.3±187.7 | 341.9±139.6 | 382.8±61.12 |
†=value significantly different vs. pre-treatment (p<0.05 by repeated measures ANOVA)
*=value significantly different vs qw (p<0.05 by Mann-Whitney)