Table 2(C).
Changes in Serum and Cellular Cytokine levels over 24 weeks of Any Interferon Therapy (n=15)
| pg/ml mean±SE | Pre-Rx mean | 4 weeks | 8 weeks | 12 weeks | 16 weeks | 20 weeks | 24 weeks | Post-Rx mean |
|---|---|---|---|---|---|---|---|---|
| Serum IL10 | 14.19±0.86 | 13.29±0.76 | 13.49±0.98 | 14.58±1.17 | 14.45±1.21 | 13.04±0.77 | 13.29±0.84 | 13.63±0.35 |
| Serum IL12p70 | 64.18±6.63 | 67.98±7.98 | 68.58±9.21 | 59.45±7.35 | 57.98±8.25 | 52.09±7.46 | 59.75±7.58 | 60.97±3.23 |
| Serum 10/12p70 | 0.232±0.018 | 0.223±0.022 | 0.236±0.030 | 0.278±0.027 | 0.297±0.029 | 0.298±0.032 | 0.263±0.030 | 0.266±0.012† |
| cellular IL10 | 394.9±85.1 | 375.7±103.9 | 371.9±87.2 | 905.0±198.4 | 1104±308.7 | 1247±390.4 | 1061±470.9 | 844.2±123.2† |
| cellular IL12p40 | 1694±306.7 | 1423±268.4 | 1142±241.8 | 1728±298.4 | 1439±206.2 | 1196±202.1 | 1031±110.2 | 1379±92.0 |
| cellular IL12p70 | 69.1±15.1 | 78.0±18.9 | 62.6±22.0 | 173.1±48.8 | 129.7±46.2 | 81.1±19.6 | 49.8±13.5 | 95.7±13.3† |
| cellular IFN-g | 803.8±168.0 | 433.3±169.2 | 241.8±71.1 | 343.1±105.6 | 263.3±69.7 | 362.4±101.4 | 341.5±101.1 | 330.9±43.4† |
†=value significantly different vs. pre-treatment (p<0.05 by repeated measures ANOVA)