Skip to main content
. Author manuscript; available in PMC: 2008 Mar 30.
Published in final edited form as: Neuroscience. 2007 Feb 9;145(3):900–910. doi: 10.1016/j.neuroscience.2006.12.048

Figure 4.

Figure 4

Second messengers in the Gs pathway suppress evoked network activity. (A) Bar chart shows the mean ± S.E. data for the effects of forskolin (direct activator of adenylyl cyclase; 10 μM; 4 minutes; N = 4) and 8-Br-cAMP (0.5 mM; 5-10 minutes; N = 4) on the fast EPSC and evoked network activity (late EPSCs). Both treatments selectively suppressed network activity (* denotes P < 0.01). (B) Averaged sweeps in voltage clamp showing that 8-Br-cAMP (0.5 mM; 5 minutes) suppresses the evoked network activity without changing the fast EPSC.