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. Author manuscript; available in PMC: 2008 Mar 30.
Published in final edited form as: Neuroscience. 2007 Feb 9;145(3):900–910. doi: 10.1016/j.neuroscience.2006.12.048

Figure 6.

Figure 6

Blocking the neuronal, but not the glial, glutamate transporter can restore evoked network activity in the presence of the D1/D5 stimulation. (A) The superimposed traces on the left show that the glial glutamate transporter inhibitor trans-PDC (6 μM; 10 minutes) cannot restore evoked network activity in the presence of SKF 38393 (100 nM). The traces on the right show that TBOA (6 μM; 5 minutes), which also blocks the neuronal glutamate transporter, can restore evoked network activity in the presence of a maximally-suppressing level of SKF 38393. (B) Bar chart shows the mean ± S.E. for the area of the fast EPSC and the excitatory component of evoked network activity (late EPSCs) during application of SKF 38393 (100 nM) in the presence of trans-PDC (6-30 μM; 10 minutes; N = 6) or TBOA (3-6 μM; 3-10 minutes; N = 5). * denotes P < 0.01.