Figure 3.

The histone acetylation pattern of the β-globin locus in MEL cells recapitulates that of fetal liver. ChIP analysis was used to define the histone acetylation pattern of the endogenous β-globin locus in MEL cells. The brain-specific necdin promoter was used as a negative control. Representative ethidium bromide-stained gels are shown. The graphs show the relative intensity of the PCR products (mean ± SEM). The number of independent determinations for HS2, Ey, βH1, βmajor, and necdin were 5, 4, 5, 7, and 6, respectively.