Table 2.
Pharmacokinetics of ritonavir after once daily administration of nelfinavir/ritonavir combinations for 14 days.*
| Values (geometric mean + range) | |||
|---|---|---|---|
| Parameter† | Group 1: nelfinavir/ritonavir2000/200 mg (n = 8) | Group 2: nelfinavir/ritonavir 2000/400 mg (n = 8) | Group 3: nelfinavir/ritonavir2500/200 mg (n = 4) |
| Ritonavir | |||
| AUC24h,corr (h.mg l−1) | 12.2 (8.2–18.3) | 32.4 (14.0–53.7) | 11.8 (7.9–23.4) |
| Cmax (mg l−1) | 1.7 (1.1–2.9) | 4.0 (2.3–5.7) | 1.8 (1.2–3.9) |
| Cmin (mg l−1) | 0.04 (0.00–0.12) | 0.15 (0.06–0.24) | 0.04 (0.02–0.13) |
| tmax (h)‡‡ | 4.0 (2.0–5.0) | 4.1 (1.0–6.0) | 5.0 (1.5–5.0) |
| CL/F.kg (l.h.kg) | 0.22 (0.16–0.35) | 0.15 (0.06–0.30) | 0.22 (0.12–0.37) |
| Vd/F.kg (l kg−1) | 1.1 (0.58–1.5) | 0.95 (0.32–2.2) | 1.3 (0.62–2.6) |
| t½ (h) | 3.4 (2.4–5.7) | 4.4 (3.7–7.0) | 4.1 (2.7–5.4) |
*
Pharmacokinetic parameters were assessed after intake of drugs with a full breakfast: 610 kcal, 33% fat, 16% proteins, 51% carbohydrates and 130 ml water (study day 15).
†
Abbreviations of pharmacokinetic parameters: seeTable 1.
‡
Median (and range).