Table 4.

Adverse events: incidence and toxicity scores.^*

	Study group
Adverse event	Group 1: nelfinavir/ritonavir 2000/200 mg (n = 9)	Group 2: nelfinavir/ritonavir 2000/400 mg (n = 9)	Group 3: nelfinavir/ritonavir 2500/200 mg (n = 8)*	All groups: (n = 26)
Incidence (any severity)†
Diarrhoea	100	78	50	77
Flatulence	56	78	38	58
Nausea	11	56	25	31
Vomiting	0	11	25	12
Abdominal pain	22	44	50	38
Asthenia	11	22	38	23
Fatigue/somnolence	22	56	75	50
Fever	0	0	13	4
Headache	56	33	25	38
Skin reaction or rash	22	33	63	38
Taste perversion	11	11	25	15
Peroral paraesthesia	33	11	13	19
Peripheral paraesthesia	22	22	13	19
Arthralgia	22	22	25	23
Myalgia	11	22	13	15
Median severity score‡	1.5	2.5	3.1	2.4

^*Data are from all participants, including those who withdrew. One participant in group 3 withdrew informed consent before taking the drugs and before the first evaluation of adverse events.

^†Incidence expressed as the percentage of participants who reported a particular adverse event at least once.

^‡A severity score of 3.0 represents three mild adverse events, or one moderate adverse event (2 points) plus a mild one, or one severe adverse event (3 points).