. 2003 Feb;55(2):182–190. doi: 10.1046/j.1365-2125.2003.01722.x

Table 1.

Absorption and other pharmacokinetic parameters of fexofenadine (mean ± s.d.) administered alone (0–100 min) or with ketoconazole (100–200 min) before (treatment 1) and after 5 days pretreatment (treatment 2) with ketoconazole.

	Treatment 1		Treatment 2
	0–100 min	100–200 min	0–100 min	100–200 min
P_eff (10⁻⁴ cm s⁻¹)	0.11 ± 0.11	0.04 ± 0.13	0.29 ± 0.47	0.22 ± 0.31
f_abs (%)	3 ± 3	1 ± 3	7 ± 10	6 ± 8
AUC₁₀₀ (ng ml⁻¹ min)	55 ± 101		51 ± 33
AUC₇₂₀ (ng ml⁻¹ min)	318 ± 426		426 ± 232

No significant differences were observed. P_eff, Effective jejunal permeability; f_abs, the fraction of drug being absorbed in the segment; AUC₁₀₀, AUC₇₂₀, area under the plasma concentration–time curve after 100 and 720 min, respectively.