Table 2.
95% confidence intervals (95% CI) on differences for the absorption and other pharmacokinetic parameters of fexofenadine.
| T1 0–100 | T1 0–100 | T1 0–100 | T1 100–200 | T1 100–200 | T2 0–100 | |
|---|---|---|---|---|---|---|
| vs | vs | vs | vs | vs | vs | |
| T1 100–200 | T2 0–100 | T2 100–200 | T2 0–100 | T2 100–200 | T2 100–200 | |
| Peff (10−4 cm s−1) | (−0.37, 0.51) | (−0.62, 0.27) | (−0.54, 0.34) | (−0.69, 0.20) | (−0.61, 0.27) | (−0.37, 0.51) |
| fabs (%) | (−8, 12) | (−14, 7) | (−13, 8) | (−16, 5) | (−15, 6] | (−9, 11) |
| AUC100 (ng ml−1 min) | (−108, 115) | |||||
| AUC720 (ng ml−1 min) | (−622, 405) |
No significant differences were observed. Peff, Effective jejunal permeability; fabs, the fraction of drug being absorbed in the segment; AUC100, AUC720, area under the plasma concentration–time curve after 100 and 720 min, respectively.