Table 3.

Mean (± s.d.) values of the absorption markers and the other perfusion parameters after treatments 1 and 2.

	Treatment 1		Treatment 2
	0–100 min	100–200 min	0–100 min	100–200 min
Peff antipyrine (10−4 cm s−1)	3.28 ± 2.44	2.24 ± 1.12	6.37 ± 3.53*	5.61 ± 4.29†
fabs antipyrine (%)	46 ± 16	36 ± 12	59 ± 12*	56 ± 21†
PEG 4000rec (%)	99 ± 12	87 ± 10	93 ± 19	110 ± 18
NWF (ml h−1 cm−1)	1.77 ± 0.58	2.21 ± 0.51	2.27 ± 0.97	1.44 ± 1.16
Qout (ml min−1)	2.35 ± 0.31	2.17 ± 0.23	2.29 ± 0.36	2.48 ± 0.29
pH	6.57 ± 0.11	6.69 ± 0.17	6.58 ± 0.08	6.66 ± 0.25
Osmolality (mOsm kg−1)	280 ± 8	260 ± 14	266 ± 17	277 ± 11

P_eff, Effective jejunal permeability; f_abs, the fraction of drug being absorbed in the segment; PEG 4000_rec, recovery of ¹⁴C-labelled PEG 4000; NWF, net water flux; Q_out, flow rate out of the segment.

^*Significantly different from treatment 1 100–200 min (P < 0.01).

^†Significantly different from treatment 1 100–200 min (P < 0.05).