Table 1.
Inclusion/exclusion criteria.
| Inclusion criteria |
| Male or female patients over 18 years & up to 75 years of age Inability to remain at the hospital for the duration of the study Hip or knee |
| Grade I-II physical status as defined by the American Society of replacement surgery under general anaesthesia (24 h) |
| Anaesthesiologists [24]Grade I-II physical status as defined by the American Society of Morphine not the drug of choice for patient-controlled analgesia |
| Written informed consentAnaesthesiologists [24] |
| Exclusion criteria |
| Inability to remain at the hospital for the duration of the study |
| Hip or knee replacement surgery under general anaesthesia (24 h) |
| Morphine not the drug of choice for patient-controlled analgesia |
| Contraindication for treatment with ketoprofen or other nonsteroidal |
| Written informed consentsteroidal anti-inflammatory drugs |
| Systemic infection or infection at the site of operation before surgery is is performed |
| Complication during or after surgical procedure |
| Patients with planned concomitant medication during the study with any of of the following: lithium, more than 300 mg acetyl salicylic acid per day, other nonsteroidal anti-inflammatory drugs, systemic glucocorticoids, methotrexate, cyclosporin, sedatives (other than short acting premedications), MAO inhibitors, inhibitors, antiepileptics |
| Allergy to ketoprofen or other nonsteroidal anti-inflammatory drugs |
| History of peptic ulcer, gastrointestinal bleeding or severe gastropathy gastropathy |
| Moderate or severe renal, hepatic or respiratory impairment in the opinion opinion of the investigator |
| Recent history of asthma, bronchospasm, angioedema or coagulation disorder |
| Diabetes mellitus, heart failure or hypertension not well controlled |
| Drug addiction or alcoholism |
| Epilepsy, psychosis or other psychiatric disorders |
| Current participation or participation within the previous 3 months in other clinical trials with unlicensed medicines or in other clinical trial with unlicensed medicines in the previous 3 months. |
| Pregnancy or lactation, including ectopic pregnancy |
| Inadequate contraception (females) |