Table 4.

Cumulative morphine usage (CAM) until 12 h after the second administration of study medication.

	Lower 95%confidence limit	Adjustedmean difference	Upper 95%confidence limit	t-tests P values
FA data set
DKP ↔ KET	−11.3	−1.6	8.1	0.74481 (0.7448)2
DKP ↔ PLC	−34.8	−25.0	−15.2	≤ 0.00031 (0.0001)2
KET ↔ PLC	−33.2	−23.4	−13.6	≤ 0.00031 (.0001)2
PP data set
DKP ↔ KET	−11.8	0.5	12.9	0.93321 (0.9332)2
DKP ↔ PLC	−35.4	−22.8	−10.2	0.00151 (0.0005)2
KET ↔ PLC	−36.1	−23.3	−10.5	0.00151 (0.0005)2

¹P values adjusted according to Bonferroni–Hochberg.

²Raw P values (not adjusted for multiplicity of testing, based on tables in Section 16.1.9)

³DKP, dexketoprofen; KET, ketoprofen.