Table 3.
Percentage inhibition of oxidative metabolism by HLM CYPs using mAbs.
| Percentage inhibition | ||||||
|---|---|---|---|---|---|---|
| Compound | Control HLM Clint(µl min−1mg−1) | CYP1A2 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A4/5 |
| Phenacetin | 9 ± 2 | 83 ± 4 | – | – | – | – |
| Diclofenac | 80 ± 18 | – | 88 ± 1 | – | – | – |
| Omeprazole | 12 ± 1 | – | – | 39 ± 4 | – | 74 ± 11 |
| Bufuralol | 20 ± 4 | – | – | – | 100, 94 | – |
| Metoprolol | 4 ± 2 | – | – | – | 100 ± 0 | – |
| Propranolol | 11 ± 2 | 35 ± 9 | – | – | 83 ± 4 | – |
| Diltiazem | 27 ± 5 | – | – | – | – | 75 ± 4 |
| Verapamil | 138 ± 35 | – | – | – | – | 67 ± 10 |
| Dextromethorphan | 22 ± 1 | – | – | – | 77, 91 | 18, 5 |
| Testosterone | 35 ± 2 | – | 13 ± 7 | – | – | 50 ± 24 |
Values represent mean ± s.d. of three experiments or data from individual experiments. –, No consistent effect with mAb observed.