Table 2.

Results from the final population PKPD model.

	Parameters		Intersubject variability		Residual variability
	Estimate	Standard error of estimate	Estimate(%)	Standard error of estimate	Estimate	Standard error of estimate
Baseline FPG (mmol l−1)			17	1
Diet alone	9.6	0.2
1 OHA class	10.9	0.1
2 OHA classes	12.2	0.2
Emax (% of baseline FPG)	29	1	30	7
Gliclazide AUC50 (µg.h ml−1)	20	3	60	47
Rate constant of equilibration keq (day−1)	0.033	0.005	84	41
Equilibration half-life (day)	21
Constant rate of disease progression in FPG (mmol l−1 year−1)	0.84	0.12	143	18
Percentage of nonresponders (%)
Diet alone	12	3
1 OHA class	24	4
2 OHA classes	50	7
Additive residual error (mmol l−1)
Responders					0.8	0.03
Nonresponders					1.7	0.06

OHA, oral hypoglycaemic agent.