Table 2.
β1-integrin-deleted cells are not able to metastasizea
Cell line | Number of injected mice | Number of mice with metastases | Site of metastasis |
---|---|---|---|
βT2 | 5 | 4 | Lung/liver |
βTi(fl/fl) | 5 | 3 | Lung |
βTN2 | 5 | 4 | Lung/liver |
βTi(Δ/Δ) | 5 | 0 | — |
The different genotype β cell lines were injected into the tail vein of athymic nu/nu mice and colonization and metastatic outgrowth in distant organs was scored. |