FIGURE 2.

dcr-1(−/−) up-regulated genes are enriched for predicted miRNA targets. The percentage of each microarray data set that were predicted miRNA targets according to the PicTar algorithm was plotted ([number of miRNA targets in data set/total genes in data set] × 100). Data for dcr-1(−/−) were analyzed after parsing into up-regulated and down-regulated genes while all misregulated genes for rde-4 and rde-1 were considered together. The random analysis is the average value using 10 independently generated random lists of genes (see Materials and Methods).