Table 2.
Genes repressed by at least 2 treatments.
| DSM code | Predicted protein | ||||
| Protein Fate | Tun 1 h | Tun 2 h | DTT | tPA | |
| Proteolytic Degradation | |||||
| An12g05960 | similar to dipeptidyl peptidase II DPPII Rattus norvegicus | *1.3 ± 0.5 | *1.6 ± 0.2 | -1.9 ± 0.3 | -1.5 ± 0.6 |
| An03g01660 | similar to vacuolar aminopeptidase Y APE3 | -2.1 ± 0.3 | *1.0 ± 0.05 | -1.7 ± 0.7 | *1.1 ± 0.02 |
| An03g05200 | similar to carboxypeptidase S1 Penicillium janthinellum | -2.1 ± 0.4 | *1.1 ± 0.4 | -1.8 ± 0.6 | *-1.4 ± 0.08 |
| An04g01440 | similar to vacuolar aspartyl protease PEP4 | -2.1 ± 0.3 | *1.1 ± 0.2 | -1.6 ± 0.04 | *-1.3 ± 0.03 |
| An08g08750 | carboxypeptidase Y CPY | -1.9 ± 0.2 | *1.0 ± 0.06 | -2.2 ± 0.02 | *-1.3 ± 0.04 |
| An14g00620 | similar to aminopeptidase Aspergillus oryzae | -2.4 ± 0.5 | *-1.0 ± 0.01 | -2.3 ± 0.1 | *-1.1 ± 0.2 |
| Lipid metabolism | |||||
| An16g01880 | similar to lysophospholipase Aspaergillus foetidus | *-2.2 ± 0.5 | -1.7 ± 0.3 | -99.8 ± 5.6 | 1.4 ± 0.8 |
| An02g09540 | similar to choline permease HNM1 | *1.1 ± 0.5 | *1.0 ± 0.6 | -2.4 ± 0.9 | -1.9 ± 0.1 |
| An16g06090 | similar to choline permease HNM1 | *-1.3 ± 0.3 | *1.1 ± 0.01 | -1.9 ± 0.2 | -2.2 ± 0.5 |
| An15g06810 | similar to cytochrome-b5 reductase MCR1 | *1.1 ± 0.2 | *1.6 ± 0.1 | -1.7 ± 0.3 | -2.6 ± 011 |
| An01g03350 | similar to C-8 sterol isomerase ERG1 Neurospora crassa | -1.9 ± 0.3 | *1.2 ± 0.2 | -2.1 ± 0.6 | *-1.2 ± 0.3 |
| An02g03580 | similar to lipid metabolism protein ERG28 | -1.8 ± 0.2 | *1.2 ± 0.02 | -2.0 ± 0.2 | *-1.3 ± 0.06 |
| An01g07000 | similar to C-14 sterol reductase ERG24 | -1.7 ± 0.1 | *1.2 ± 0.2 | *3.9 ± 0.4 | -1.9 ± 0.08 |
| Cell wall | |||||
| An16g03370 | similar to protein involved in of cell wall biogenesis CWH43 | -2.0 ± 0.2 | *1.2 ± 0.1 | -2.4 ± 0.1 | *-1.2 ± 0.01 |
| An16g07040 | similar to cell wall glucanase SCW10 | -1.7 ± 0.1 | *-1.1 ± 0.07 | -4.0 ± 0.5 | *-1.0 ± 0.04 |
| Amino acid metabolism | |||||
| An04g00990 | NADP-dependent glutamate dehydrogenase GDHA | *1.1 ± 0.3 | *-3.5 ± 2.0 | -3.6 ± 0.7 | -1.5 ± 0.005 |
| An16g01610 | similar to hydroxylase BBH Rattus norvegicus | *-1.2 ± 0.5 | -2.5 ± 0.7 | -13.5 ± 0.1 | *-1.0 ± 0.5 |
| An01g14730 | similar to lactonizing enzyme I TcMLE Trichosporon cutaneum | -1.6 ± 0.1 | *-1.3 ± 0.1 | -1.5 ± 0.2 | *1.3 ± 0.2 |
| An02g00190 | similar to enantiomer-selective amidase AMDA Rhodococcus sp. | -2.9 ± 0.5 | *1.1 ± 0.2 | -2.3 ± 0.3 | *-1.3 ± 0.5 |
| An12g10000 | similar to GABA permease GABA Aspergillus nidulans | *-1.0 ± 0.08 | *1.0 ± 0.1 | -5.5 ± 1.9 | -1.8 ± 0.09 |
| Phosphate Metabolism | |||||
| An12g01910 | similar to phytase PHYA3 Aspergillus fumigatus | -1.5 ± 0.1 | -1.6 ± 0.3 | -21.1 ± 2.5 | *-1.0 ± 0.1 |
| C-compound and carbohydrate metabolism | |||||
| An09g00270 | alpha-galactosidase AGLC | *-1.2 ± 0.1 | -2.0 ± 0.5 | -5.9 ± 2.0 | *1.1 ± 0.3 |
| An09g00260 | alpha-galactosidase AGLC | *-2.6 ± 0.5 | -2.1 ± 0.3 | -6.0 ± 4.3 | *1.1 ± 0.2 |
| An01g01540 | similar to alpha.alpha-trehalase TREA A. nidulans | -3.0 ± 0.6 | *-1.1 ± 0.1 | -2.7 ± 0.6 | *1.2 ± 0.02 |
| An01g00780 | endo-1.4-xylanase XYNB | -3.4 ± 0.6 | *1.5 ± 0.4 | -4.3 ± 0.9 | *1.0 ± 0.1 |
| An05g00930 | similar to mitochondrial malic enzyme MAE1 | -2.1 ± 0.2 | *1.2 ± 0.1 | -4.0 ± 1.0 | *-1.0 ± 0.04 |
| An19g00090 | similar to exo-beta-1.3-glucanase CMG1 Coniothyrium minitans | -2.6 ± 0.3 | *1.6 ± 0.1 | -4.6 ± 1.0 | *3.7 ± 0.06 |
| An11g04780 | similar to protein involved in active glycerol uptake GUP1 | -1.7 ± 0.2 | *1.2 ± 0.2 | -2.4 ± 0.3 | *1.0 ± 0.1 |
| metabolism of vitamins. cofactors. and prosthetic groups | |||||
| An01g04250 | similar to uroporphyrinogen decarboxylase HEM12 | *-1.2 ± 0.06 | *1.1 ± 0.04 | -1.6 ± 0.1 | -1.6 ± 0.1 |
| Cellular transport | |||||
| An12g10320 | similar to high-affinity zinc transport protein ZRT1 | *1.1 ± 0.05 | *1.4 ± 0.04 | -2.2 ± 0.04 | -3.2 ± 1.1 |
| An16g06740 | similar to cadmium resistance protein YCF1 | *-1.4 ± 0.2 | *-1.7 ± 0.5 | -1.7 ± 0.2 | -1.7 ± 0.3 |
| Cell Rescue. Defense and Virulence | |||||
| An07g00570 | similar to membrane protein PTH11 Magnaporthe grisea | *-1.1 ± 0.1 | *-1.0 ± 0.04 | -2.7 ± 0.06 | -2.0 ± 0.1 |
| An18g00980 | similar to membrane protein PTH11 M. grisea | *-3.0 ± 0.5 | *1.4 ± 0.2 | -4.6 ± 0.2 | -2.0 ± 0.1 |
| An16g05920 | similar to membrane protein PTH11 M. grisea | *1.1 ± 0.2 | -3.9 ± 1.1 | -5.5 ± 1.1 | *1.0 ± 0.08 |
| Nucleotide/nitrogen and sulfur metabolism | |||||
| An10g00800 | similar to purine nucleoside permease NUP Candida albicans | -5.4 ± 0.8 | *-1.5 ± 0.07 | -31.9 ± 2.7 | *1.2 ± 0.1 |
| An18g01220 | similar to allantoate permease DAL5 | -1.6 ± 0.1 | *1.6 ± 0.2 | -4.2 ± 0.06 | *-1.2 ± 0.05 |
| Other | |||||
| An07g06530 | similar to multicopy suppressor SUR7 | *2.0 ± 0.4 | *1.7 ± 0.2 | -5.0 ± 1.9 | -1.6 ± 0.1 |
| An16g05910 | similar to putative cytochrome P450 A. fumigatus | *-1.2 ± 0.08 | -2.3 ± 0.5 | -5.8 ± 0.2 | *2.2 ± 0.05 |
| An11g09870 | similar to palmitoleyltransferase ERF2 | -1.6 ± 0.1 | *1.4 ± 0.2 | -2.1 ± 0.3 | *1.0 ± 0.01 |
| Unclassified | |||||
| An02g03570 | similar to membrane protein YBR159w | -2.1 ± 0.2 | *-1.3 ± 0.3 | *-1.9 ± 1.0 | -1.6 ± 0.2 |
| An11g07340 | similar to hypothetical O-methyl transferase ENCK | *1.3 ± 0.1 | *1.3 ± 0.5 | -4.2 ± 0.6 | -4.2 ± 1.7 |
| An12g09640 | similar to hypothetical GTP cyclohydrolase | *2.6 ± 0.5 | *1.3 ± 0.4 | -3.3 ± 0.2 | -1.9 ± 0.5 |
| An01g09220 | weakly similar to tyrosinase MELC2 | *-2.1 ± 0.5 | *2.1 ± 0.2 | -5.2 ± 1.7 | -1.8 ± 0.4 |
| An03g00770 | similar to allergic allergen rAsp f 4 A. fumigatus | *-2.3 ± 0.6 | *-1.1 ± 0.3 | -2.6 ± 0.1 | -2.8 ± 0.6 |
| An08g03760 | hypothetical protein | *-1.1 ± 0.1 | *-1.3 ± 0.07 | -4.0 ± 1.8 | -2.4 ± 0.3 |
| An02g08330 | hypothetical protein | *1.2 ± 0.2 | *-17 ± 11.3 | 13.5 ± 5.2 | -1.8 ± 0.1 |
| An06g01000 | hypothetical protein | *-1.1 ± 0.1 | *-1.0 ± 0.05 | -1.83 ± 0.5 | -2.3 ± 0.1 |
| An11g07020 | hypothetical protein | *1.3 ± 0.3 | *1.2 ± 0.02 | -2.1 ± 0.3 | -1.8 ± 0.2 |
| An02g08300 | hypothetical protein | *2.2 ± 0.5 | *-1.7 ± 0.3 | -3.2 ± 0.8 | -8.6 ± 0.9 |
| An03g00840 | hypothetical protein | 1.8 ± 0.2 | *-1.2 ± 0.2 | *1.3 ± 0.1 | -2.4 ± 0.9 |
| An18g01000 | hypothetical protein | *-2.4 ± 0.5 | *1.1 ± 0.1 | -4.6 ± 0.5 | -1.8 ± 0.2 |
| An13g01520 | hypothetical protein | -1.5 ± 0.1 | *-2.9 ± 0.2 | *-1.0 ± 0.4 | -1.9 ± 0.2 |
| An02g00120 | hypothetical protein | -2.4 ± 0.5 | *1.2 ± 0.3 | -2.0 ± 0.5 | *-1.8 ± 0.07 |
| An04g01690 | hypothetical protein | -2.1 ± 0.4 | *-1.0 ± 0.3 | -3.1 ± 1.1 | *-1.1 ± 0.03 |
| An05g01770 | hypothetical protein | -1.5 ± 0.1 | *-1.5 ± 0.3 | -5.8 ± 1.0 | *1.0 ± 0.5 |
| An07g05160 | hypothetical protein | -1.7 ± 0.1 | *-1.2 ± 0.2 | -2.1 ± 0.05 | *1.0 ± 0.08 |
| An07g08400 | strong similarity to allergen rAsp f 4 A. fumigatus | -1.8 ± 0.2 | *1.3 ± 0.2 | -4.2 ± 1.2 | *1.1 ± 0.07 |
| An08g08600 | similar to RTN2 | -1.9 ± 0.2 | *-1.0 ± 0.01 | -3.3 ± 0.6 | *-1.0 ± 0.1 |
| An12g10590 | hypothetical protein | -2.6 ± 0.4 | *1.1 ± 0.03 | -12.0 ± 2.1 | *1.0 ± 0.02 |
| An15g01740 | similar to ER protein of unknown function | -1.6 ± 0.1 | *1.4 ± 0.1 | -2.1 ± 0.3 | *1.0 ± 0.1 |
The fold changes in expression are indicated for all the treatments (Tun = tunicamycin, DTT = dithiothreitol, tPA = production of t-PA) and are averaged over two experiments. Similarities are expressed in comparison with the Saccharomyces cerevisiae genome except when indicated. The symbol* indicates that the value does not meet one of the 3 restrictive criteria defined in the Method section.