Table 1.
Absolute leukocyte counts following 5-FU treatment with or without myeloid progenitor infusion
|
5-FU only
|
5-FU + CMP/GMP
|
|||
|---|---|---|---|---|
| D + 8* | D + 13† | D + 8* | D + 13† | |
| Blood | ||||
| Absolute WBC counts, × 103/μL; range: 5.5-9.3 | 4.1 ± 0.4 | 12.0 ± 1.6 | 5.4 ± 0.5 | 13.0 ± 0.6 |
| Absolute neutrophil counts, × 103/μL; range: 0.825-2.604 | 0.002 ± 0.007 | 3.6 ± 0.8 | 0.03 ± 0.01 | 2.6 ± 0.5 |
| Spleen | ||||
| Absolute splenocytes, × 108 | 3.3 ± 0.4 | ND | 4.5 ± 1.1 | ND |
| Total Mac-1+ Gr-1+, × 106 | 0.6 ± 0.2 | ND | 1.2 ± 0.3‡ | ND |
| CMP/GMP-derived, × 105 | - | - | 6.5 ± 2.0 (54)§ | ND |
Data are mean absolute cell counts plus or minus standard error of the mean (SEM).
ND indicates not determined; -, population not present; ND, not measured.
For D + 8/Blood, n = 15 for 5-FU only and n = 9 for 5-FU + CMP/GMP. For D + 8/Spleen, n = 14 for 5-FU only and n = 10 for 5-FU + CMP/GMP
For D + 13/Blood, n = 7 for 5-FU only and n = 5 for 5-FU + CMP/GMP
Significant difference from D + 8 counts (P = .02)
Value in parentheses indicates the percentage of total Mac-1+ Gr-1+ cells