Table 1.

Effect of 8-Cl-Ado on the RNA inhibition

	RNA synthesis, % mean
Patient no.	0 h (dpm/106 cells)	2 h	4 h
1	100 (1360)	67	40
2	100 (1502)	60	35
3	100 (2805)	57	32
4	100 (648)	55	42
5	100 (3450)	62	37

Primary CLL cells of patients 1 to 5 were isolated and the cells (5 × 10⁶/500 μL) were incubated without drug or with 10 μM of 8-Cl-Ado for 2- and 4-hour periods and pulsed with [³H] uridine for 30 minutes. At the end of incubation the uridine incorporation into RNA was measured. The values are expressed as percentage of control (untreated) cells.