Table 6.

Autologous T-cell proliferation in the presence of MVA-TRICOM–infected CLL cells

Patient, stimulator cells	Autologous stimulation index
2
Uninfected	1.0
MVA-WT	0.5
MVA-TRICOM	34.8
8
Uninfected	1.3
MVA-WT	1.6
MVA-TRICOM	30.6
16
Uninfected	1.7
MVA-WT	1.3
MVA-TRICOM	27.2
13
Uninfected	1.1
MVA-WT	1.0
MVA-TRICOM	13.4
14
Uninfected	1.3
MVA-WT	0.7
MVA-TRICOM	5.3
12
Uninfected	1.1
MVA-WT	1.3
MVA-TRICOM	4.2
19
Uninfected	1.7
MVA-WT	1.3
MVA-TRICOM	2.3
10
Uninfected	0.7
MVA-WT	NA
MVA-TRICOM	2.2
18
Uninfected	1.0
MVA-WT	1.1
MVA-TRICOM	1.9
17
Uninfected	1.1
MVA-WT	1.3
MVA-TRICOM	1.4

CD3⁺ T cells from patients with CLL were stimulated with uninfected, MVA-WT-, or MVA-TRICOM–infected CLL cells, at a ratio of stimulator to effector cells equal to 1:2.5. Proliferation was measured as ³H-thymidine incorporation on day 5 of culture. Stimulation index was calculated as cpm (T cells + CLL cells)/cpm (T cells alone).

NA indicates not available.