Table 2.
Correlation of gene expression for the thioredoxin-related proteins with the worst prognosis, as measured by the patient outcome predictor scores
|
Average expression on microarray†
|
Statistical significance
|
||||
|---|---|---|---|---|---|
| Gene | Best prognosis, 10% | Worst prognosis, 10% | t test, best 10% vs worst 10%, P | Regression, all patients, P | Correlation with poor prognosis |
| Thioredoxin (TRX) | –0.055 | 0.0994 | .397 | .15 | Increasing trend |
| Vitamin D3 up-regulated protein 1 (VDUP1/TIP/TBP2) | 0.1916 | –0.6775 | < .001* | .005* | Significant decrease |
| Thioredoxin reductase 1 (TRXR1) | 0.1648 | 0.0036 | .177 | .098 | Decreasing trend |
| Thioredoxin reductase 2 (TRXR2) | 0.0719 | –0.1768 | .033* | .491 | Significant decrease/no change |
*
Significant P value
†
Values are on a log2 scale