Table 5.
Risk of breast cancer among women diagnosed with HL at age 30 years or younger who had a live birth, according to timing of live births
| Patients, no (%) | Matched control subjects, no. (%) | Odds ratio, adjusted*(95% CI) | |
|---|---|---|---|
| Among women who did not receive AA or RT to ovaries ≥ 5 Gy, and also had ≥ 1 live birth: patients (n = 50) and matched control subjects (n = 96) | |||
| Most recent live birth preceding HL† | |||
| Live birth 16 mos. or more | 13 (54.2) | 16 (43.2) | 1.0 |
| Live birth 16 mos. or less | 10 (41.7) | 16 (43.2) | 1.2 (0.40-3.4) |
| Unknown | 1 (4.1) | 5 (13.6) | — |
| Among women who did not receive AA and who received < 5 Gy RT to ovaries, and also had ≥ 1 live birth: patients (n = 50) and matched control subjects (n = 96) | |||
| Most recent live birth following HL† | |||
| Live birth later than 60 mos. | 10 (27.0) | 33 (44.6) | 1.0 |
| Live birth at 60 mos. or earlier | 25 (67.6) | 33 (44.6) | 2.6 (1.0-6.7) |
| Unknown | 2 (5.4) | 8 (10.8) | — |
| Among women who did not receive AA and who received < 5 Gy RT to ovaries, and had ≥ 1 live birth: Patients (n = 50) and matched control subjects (n = 96) | |||
| Time elapsed btw, most recent live birth and BC diagnosis/control cutoff date, y | |||
| 20 or more | 11 (22.0) | 20 (20.8) | 1.0 |
| 15-19 | 16 (32.0) | 23 (24.0) | 1.0 (0.3-3.6) |
| 10-14 | 8 (16.0) | 18 (18.8) | 0.5 (0.1-2.8) |
| 5-9 | 8 (16.0) | 10 (10.4) | 0.9 (0.2-4.4) |
| 5 or less | 6 (12.0) | 13 (13.5) | 0.6 (0.1-7.4) |
| Unknown parity or timing of most recent birth | 1 (2.0) | 12 (12.5) | — |
—indicates not calculated; BC, breast cancer.
*
Analyses were adjusted for age at first live birth (≤ 22y, 23-26y, and ≥ 27y).
†
Columns do not add to 50 patients and 96 control subjects because some women had a live birth both before and after HL, and are counted in both analyses, while others are counted only once.