Table 3.

Comparison of TAP-ANV and a combination of TAP and ANV in TF-initiated plasma clotting, aPTT, and a mouse thrombosis model

	TF-initiated clotting time,*s	aPTT,†s	Occlusion time,‡min
Control	42.3 ± 1.3 (n = 7)	33.2 ± 1.0 (n = 4)	57 ± 10.2 (n = 5)
TAP-ANV	60.7 ± 1.2 (n = 7)§	52.8 ± 2.1 (n = 4)§	80 ± 13.5 (n = 6)§
TAP + ANV	42.5 ± 0.6 (n = 7)	36.9 ± 0.9 (n = 4)§	49 ± 2.4 (n = 5)

Values are mean ± SD.

^*Plasma was supplemented with buffer (control), 2.5 nM fusion protein (TAP-ANV), or 2.5 nM TAP and 2.5 nM ANV (TAP + ANV), and the TF-initiated clotting was determined using a fibrometer

^†Plasma was supplemented with buffer (control), 50 nM fusion protein (TAP-ANV), or 50 nM TAP and 50 nM ANV (TAP + ANV), and the aPTT was determined using a fibrometer

^‡Mice were injected with PBS (control), 0.23 nmol/kg (10 μg/kg) fusion protein (TAP-ANV), or a mixture of 0.23 nmol/kg TAP and 0.23 nmol/kg ANV (TAP + ANV), and the occlusion time was determined as described in “Materials and methods”

^§P ≤ .01 versus control (2-tailed t test)