Table 1.

Activation sites of pro-tryptase ε, pro-uPA, pro-tPA, and plasminogen

	Zymogen processing site
↓
Protease	propeptide-P1-P1′-P2′-P3′-P4′-P5′-mature domain
Human pro-tryptase ε	Arg-Val-Val-Gly-Gly-Glu
Rat pro-tryptase ε	Arg-Val-Val-Gly-Gly-Glu
Mouse pro-tryptase ε	Arg-Ile-Val-Gly-Gly-Glu
Mouse pro-uPA	Lys-Ile-Val-Gly-Gly-Glu
Rat pro-uPA	Lys-Ile-Val-Gly-Gly-Glu
Human pro-uPA	Lys-Ile-Ile-Gly-Gly-Glu
Human pro-tPA	Arg-Ile-Lys-Gly-Gly-Leu
Mouse pro-tPA	Arg-Ile-Lys-Gly-Gly-Leu
Rat pro-tPA	Arg-Ile-Lys-Gly-Gly-Leu
Human plasminogen	Arg-Val-Val-Gly-Gly-Cys
Mouse plasminogen	Arg-Val-Val-Gly-Gly-Cys
Rat plasminogen	Arg-Val-Val-Gly-Gly-Cys
Danio rerio plasminogen	Arg-Ile-Val-Gly-Gly-Cys