Table 2.
Association of IL-10/-592 and IL10RB/c238 genotypes with grades III-IV acute GVHD
| Genotype (number) | Incidence of GVHD, % | Hazard ratio | Trend P* |
|---|---|---|---|
| Patient genotype | |||
| IL-10/-592 | <.001 | ||
| C/C (504) | 22 | Reference | |
| A/C (368) | 16 | 0.7 (0.5-0.9) | |
| A/A (81) | 10 | 0.4 (0.2-0.8) | |
| IL10RB/c238 | .31 | ||
| A/A (494) | 21 | Reference | |
| A/G (385) | 16 | 0.8 (0.6-1.0) | |
| G/G (74) | 20 | 1.0 (0.6-1.7) | |
| Donor genotype | |||
| IL-10/-592 | .03 | ||
| C/C (492) | 21 | Reference | |
| A/C (371) | 17 | 0.8 (0.6-1.1) | |
| A/A (90) | 13 | 0.6 (0.3-1.0) | |
| IL10RB/c238 | .02 | ||
| A/A (515) | 21 | Reference | |
| A/G (356) | 17 | 0.8 (0.5-1.0) | |
| G/G (82) | 12 | 0.6 (0.3-1.1) |
*
Multivariable proportional hazard regression analysis adjusted for age at transplantation, transplantation year, sex mismatch, use of total body irradiation in the conditioning regimen, and disease risk group