Table 3.
IL-10/-592 and IL10RB/c238 allele and genotype frequencies according to ethnic group
| Allele and genotype frequencies | African American | Native American | Asian | White | Hispanic | Combined population | P* |
|---|---|---|---|---|---|---|---|
| Patients | |||||||
| No. | 17 | 19 | 24 | 814 | 46 | 953 | |
| IL-10/-592 allele, % | < .001 | ||||||
| C | 52.9 | 60.5 | 31.3 | 75.3 | 67.4 | 72.2 | |
| A | 47.1 | 39.5 | 68.8 | 24.7 | 32.6 | 27.8 | |
| IL-10/–592 genotype, no. (%) | < .001 | ||||||
| C/C | 5 (29) | 8 (42) | 2 (8) | 460 (57) | 21 (46) | 504 (53) | |
| A/C | 8 (47) | 7 (37) | 11 (46) | 306 (38) | 20 (40) | 368 (39) | |
| A/A | 4 (24) | 4 (21) | 11 (46) | 48 (6) | 5 (11) | 81 (8) | |
| IL10RB/c238 allele, % | .001 | ||||||
| A | 76.5 | 44.7 | 52.1 | 74.4 | 67.4 | 72.0 | |
| G | 23.5 | 55.3 | 47.9 | 25.6 | 32.6 | 38.0 | |
| IL10RB/c238 genotype, no. (%) | < .001 | ||||||
| A/A | 10 (59) | 4 (21) | 8 (33) | 447 (55) | 18 (39) | 494 (52) | |
| A/G | 6 (35) | 9 (47) | 9 (38) | 318 (39) | 26 (57) | 385 (40) | |
| G/G | 1 (6) | 6 (32) | 7 (29) | 49 (6) | 2 (4) | 74 (8) | |
| Donors | |||||||
| IL-10/-592 allele, % | < .001 | ||||||
| C | 38.2 | 63.2 | 37.5 | 74.3 | 64.1 | 71.1 | |
| A | 61.8 | 36.8 | 62.5 | 25.7 | 35.9 | 28.9 | |
| IL-10/-592 genotype, no. (%) | < .001 | ||||||
| C/C | 2 (12) | 8 (42) | 1 (4) | 454 (56) | 19 (41) | 492 (52) | |
| A/C | 9 (53) | 8 (42) | 16 (67) | 302 (37) | 21 (46) | 371 (39) | |
| A/A | 6 (35) | 3 (16) | 7 (29) | 58 (7) | 6 (13) | 90 (9) | |
| IL10RB/c238 allele, % | < .001 | ||||||
| A | 82.4 | 55.3 | 45.8 | 74.8 | 67.4 | 72.7 | |
| G | 17.6 | 44.7 | 54.2 | 25.2 | 32.6 | 27.3 | |
| IL10RB/c238 genotype, no. (%) | < .001 | ||||||
| A/A | 11 (65) | 6 (32) | 7 (29) | 459 (56) | 20 (43) | 515 (54) | |
| A/G | 6 (35) | 9 (47) | 8 (33) | 300 (37) | 22 (48) | 356 (37) | |
| G/G | 0 (0) | 4 (21) | 9 (38) | 55 (7) | 4 (8) | 82 (9) |
*
Comparison between white patients and Asian patients by chi-square test or Fisher exact test