Table 4.
Association of patient IL-10/-592 and donor IL10RB/c238 genotypes with risk of grades III-IV acute GVHD
|
Genotype
|
White patients
|
Combined patient population
|
|||||
|---|---|---|---|---|---|---|---|
| Patient IL-10/-592 | Donor IL10RB | Incidence of GVHD, % (no. of cases) | Hazard ratio*(95% CI) | P† | Incidence of GVHD, % (no. of cases) | Hazard ratio (95% CI)* | P† |
| C/C | A/A | 22 (269) | Reference | 22 (292) | Reference | ||
| C/C | A/G | 25 (164) | 1.1 (0.8-1.7) | .53 | 22 (183) | 1.0 (0.7-1.5) | .96 |
| C/C | G/G | 26 (27) | 1.1 (0.5-2.5) | .75 | 24 (29) | 1.1 (0.5-2.2) | .96 |
| A/C | A/A | 22 (165) | 0.9 (0.6-1.4) | .78 | 22 (190) | 0.9 (0.6-1.4) | .77 |
| A/C | A/G | 9 (118) | 0.4 (0.2-0.7) | .001 | 11 (141) | 0.4 (0.2-0.7) | .001 |
| A/C | G/G | 4 (23) | 0.2 (0-1.4) | .03 | 8 (37) | 0.4 (0.1-1.2) | .05 |
| A/A | A/A | 12 (25) | 0.5 (0.2-1.5) | .17 | 15 (33) | 0.6 (0.2-1.5) | .25 |
| A/A | A/G | 11 (18) | 0.5 (0.1-2.2) | .33 | 9 (32) | 0.4 (0.1-1.3) | .09 |
| A/A | G/G | 0 (5) | 0 (0) | .12 | 0 (16) | 0 (0) | .006 |
CI indicates confidence interval. For white patients, n = 814; for the combined patient population, n = 953.
*
Compared with cases with a patient IL-10/–592 C/C genotype and a donor IL10RB/c238 A/A genotype
†
Multivariable proportional hazard regression analysis adjusted for age at transplantation, transplantation year, sex mismatch, use of total body irradiation in the conditioning regimen, and disease risk group