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. 2005 May 10;106(4):1268–1277. doi: 10.1182/blood-2004-11-4434

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Copyright © 2005, The American Society of Hematology

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Figure 6. — Low levels of GPVI reduce deposition of platelets on collagen under shear stress. Whole blood from the indicated mice was perfused over collagen-coated glass slides at wall shear rates at and between 400 and 1300 s^–1 for 4 minutes. (A) Percent surface coverage of GPVI-FcRγ^–/– (▪), low-GPVI (□), and wild-type () platelets. The results shown are the mean ± SEM after analysis of the phase-contrast images (n = 5). Statistical significance was seen between GPVI-FcRγ^–/–, low-GPVI, and wild-type at and between 400 s^–1 and 1300 s^–1 (P < .01). (B) Representative phase-contrast images after flow. The lines seen in the upper left portions of some panels are visual artifact and do not arise due to abnormalities in the collagen-coated surface.

Inline graphic — Low levels of GPVI reduce deposition of platelets on collagen under shear stress. Whole blood from the indicated mice was perfused over collagen-coated glass slides at wall shear rates at and between 400 and 1300 s^–1 for 4 minutes. (A) Percent surface coverage of GPVI-FcRγ^–/– (▪), low-GPVI (□), and wild-type () platelets. The results shown are the mean ± SEM after analysis of the phase-contrast images (n = 5). Statistical significance was seen between GPVI-FcRγ^–/–, low-GPVI, and wild-type at and between 400 s^–1 and 1300 s^–1 (P < .01). (B) Representative phase-contrast images after flow. The lines seen in the upper left portions of some panels are visual artifact and do not arise due to abnormalities in the collagen-coated surface.