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Rottlerin decreases IFN-γ levels in aplastic anemia T cells. We examined the effect of rottlerin on intracellular IFN-γ levels using flow cytometric analysis in PBMCs from aplastic anemia patients (n = 4). In patients with increased IFN-γ levels (3 of 4 patients examined), rottlerin diminished IFN-γ by approximately 50%. A representative experiment of all patients and controls examined is shown. Blue indicates CD4+; green, CD8+.
