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. 2005 Sep 6;107(1):222–231. doi: 10.1182/blood-2005-05-1923

Figure 2.

Figure 2.

Time- and concentration-dependent induction of apoptosis by brefeldin A in primary CLL cells in comparison with normal cells. (A-B) Time course of apoptosis induction by various concentrations of brefeldin A in primary CLL cells. Drug-induced apoptosis was quantitated by flow cytometric analysis of caspase-3 activation (A) and annexin V-FITC/PI double-staining (B). n = 3; error bars indicate SEM. (C-D) Normal human peripheral blood mononuclear cells (PBMCs) and fibroblasts were treated with the indicated concentrations of brefeldin A for 48 hours. Drug-induced apoptosis was quantitated by flow cytometric analysis of caspase-3 activation (C) and annexin V-FITC/PI double-staining (D). Error bars indicate the SEM.