Table 5.
Relationship between triplet mismatches and corrected count increments
|
No. transfusions analyzed
|
HIMMs
|
TMMs
|
|||||
|---|---|---|---|---|---|---|---|
| CCIs < 8 | CCIs ≥ 8 | Median when CCIs < 8 | Median when CCIs ≥ 8 | p2 value | Median when CCIs < 8 | Median when CCIs ≥ 8 | p2 value |
| 145 | 378 | 6 (4-10) | 4 (2-6) | < .001 | 13 (9-18) | 11 (6-14) | < .001 |
| 122* | 246* | 6 (4-9) | 4 (1-6) | < .001 | 13 (8-18) | 12 (4-15) | = .001 |
N = 523. CCIs were calculated for all platelet transfusions. HLAMatchmaker examined HLA compatibility at the triplet level for all donor-recipient pairs and determined the number of highly immunogenic triplet mismatches as well as the total number of triplet mismatches. Transfusions were divided into 2 groups: CCIs less than 8 or CCIs at least 8. The median number of HIMMs and TIMMs are presented, with the first and third quartile values (in parentheses). The 2 cohorts were compared using unpaired, 2-tailed Student t test. The median number of HIMMs and TIMMs are presented, with the first and third quartile values in parentheses.
Data presented for all transfusions with the exclusion of patient 11