Table 3.

Summary of tandutinib dose escalation

Dose level, mg twice daily	No. of patients	No. of patients with DLTs	No. of patients with FLT3-ITD
50	6	0	0
100	3	0	0
150	6	1	1
200	3	0	0
250	3	0	0
300	6	1	1
400	4	0	1
525	6	1	3
700	3	3	2
Total	40	6	8