Table 2.
Cumulative dose comparison of key drugs
| Drug | CCG 1883 | CCG 1953 |
|---|---|---|
| Cyclophosphamide, g/m2 | 11 | 9.5 |
| Daunomycin*, mg/m2 | ||
| 3 mo or less | 87.5 | 160 |
| 4 to less than 6 mo | 125 | 166 |
| 6 to less than 9 mo | 125 | 193 |
| 9 to less than 12 mo | 125 | 218 |
| l-asparaginase, units/m2 | 132 000 | 108 000 |
| Etoposide, mg/m2 | 0 | 2 500 |
| Cytosine arabinoside, g/m2 | ||
| Less than 6 mo | 12 | 24 |
| 6 to less than 12 mo | 24 | 24 |
| Dexamethasone, mg/m2 | 0 | 700 |
| Prednisone, mg/m2 | 8 820 | 2 400 |
| Intravenous methotrexate, g/m2 | 134.6 | 142.4 |
*
CCG 1953 values are estimated conversions based on final protocol dosages.