Table 1.
Baseline patient characteristics
|
No. of patients/total no. (%)
|
|||
|---|---|---|---|
| Characteristics | MGUS | SMM | MM |
| Age 65 y or older | 5/14 (36) | 7/31 (23) | 115/479 (24) |
| Female sex | 6/14 (43) | 17/31 (55) | 205/479 (43) |
| White race | 12/14 (86) | 29/31 (94) | 429/479 (90) |
| IgA subtype | 0/8 (0) | 6/26 (23) | 120/475 (25) |
| B2M level 4 mg/L or more | 1/14 (7) | 0/31 (0) | 146/479 (30) |
| CRP level 4 mg/L or more | 0/14 (0) | 3/31 (10) | 43/479 (9) |
| Creatinine level 2 mg/dL or more | 2/13 (15) | 0/30 (0) | 51/475 (11) |
| LDH level 190 IU/L or more | 5/14 (36) | 3/31 (10) | 148/479 (31) |
| ALB level less than 3.5 g/dL | 0/12 (0) | 3/31 (10) | 157/463 (34) |
| HGB level less than 10 g/dL | 0/14 (0) | 3/31 (10) | 135/479 (28) |
| CA | 1/13 (8) | 1/29 (3) | 148/440 (34) |
| Hyperdiploidy* | 0/13 (0) | 1/29 (3) | 79/440 (18) |
| Hypodiploidy* | 1/13 (8) | 0/29 (0) | 52/440 (12) |
| PC in BM aspirate 33% or more | 0/14 (0) | 6/28 (21) | 183/402 (46) |
| PC in BM biopsy 33% or more | 0/14 (0) | 0/28 (0) | 193/402 (48) |
To convert β2-microglobulin level from milligrams per liter to nanomoles per liter, multiply milligrams per liter by 85. To convert creatinine level from milligrams per deciliter to micromoles per liter, multiply milligrams per liter by 88.4. To convert albumin and hemoglobin levels from grams per deciliter to grams per liter, multiply grams per deciliter by 10.
B2M indicates serum β2-microglobulin; CRP, C-reactive protein; LDH, serum lactate dehydrogenase; ALB, serum albumin; HGB, hemoglobin; CA, cytogenetic abnormalities defined by G banding; PC, plasma cells; BM, bone marrow
*
Ploidy was defined by G banding