Table 2.

Baseline patient characteristics according to Amp1q21 in newly diagnosed MM

	No. of patients/total no. (%)
Characteristics	No Amp1q21*	Amp1q21	P
Age, 65 y or older	62/274 (23)	53/205 (26)	.413
Female sex	107/274 (39)	98/205 (48)	.055
White race	241/274 (88)	188/205 (92)	.184
IgA subtype	53/274 (19)	67/201 (33)	< .001
B2M level 4 mg/L or more	68/274 (25)	78/205 (38)	.002
CRP level 4 mg/L or more	24/274 (9)	19/205 (9)	.847
Creatinine level 2 mg/dL or more	24/272 (9)	27/203 (13)	.119
LDH level 190 IU/L or more	67/274 (24)	81/205 (40)	< .001
ALB level less than 3.5 g/dL	80/265 (30)	77/198 (39)	.050
HGB level less than 10 g/dL	63/274 (23)	72/205 (35)	.004
CA	66/253 (26)	82/187 (44)	< .001
Hyperdiploidy†	35/253 (14)	44/187 (24)	.009
Hypodiploidy†	16/253 (6)	36/187 (19)	< .001
PC in BM aspirate 33% or more	107/251 (43)	76/151 (50)	.133
PC in BM biopsy 33% or more	105/246 (43)	88/156 (56)	.007
del(13)‡	37/252 (15)	67/184 (36)	< .001
Focal bone lesions by MRI, 3 or more	140/265 (53)	107/196 (55)	.708
ISS stage 1	140/265 (53)	73/202 (36)	< .001
ISS stage 2	83/265 (31)	73/202 (36)	.274
ISS stage 3	42/265 (16)	56/202 (28)	.002

MRI indicates magnetic resonance imaging; other abbreviations are explained in Table 1.

To convert β2-microglobulin level from milligrams per liter to nanomoles per liter, multiply milligrams per liter by 85. To convert creatinine level from milligrams per deciliter to micromoles per liter, multiply milligrams per liter by 88.4. To convert albumin and hemoglobin levels from grams per deciliter to grams per liter, multiply grams per deciliter by 10

^*Amp1q21: at least 3 copies of 1q21 defined by interphase FISH

^†Ploidy was defined by G banding

^‡del(13): at least 80% of cells with up to 1 copy of D13S31 by interphase FISH