Table 2.

DNA repair pathways and genetic variants examined in relation to risk of non-Hodgkin lymphoma

Substitutions according to gene (gene symbol; location)	RS no.
Nonhomologous end joining/V(D)J
DNA ligase IV (LIG4; 13q33)
T91	rs1805388
Recombination-activating gene 1* (RAG1; 11p13)
K820R	rs2227973
X-ray repair cross-complementing 4 (XRCC4; 5q13)
N298S	rs1805377
S307	rs1056503
A247S	rs3734091
Homologous recombination repair
Breast cancer 2, early onset (BRCA2; 13q12.3)
N372H	rs144848
K1132	rs1801406
S2414	rs1799955
Ex27-336A>C	rs15869
N289H	rs766173
N991D	rs1799944
Nijmegen breakage syndrome (NBS1; 8q21)
E185Q	rs1805794
Tumor protein p53 (TP53; 17p13.1)
P72R	rs1042522
Werner syndrome (WRN; 8p12)
V114I	rs4987236
M387I	rs1800391
L1074F	rs2725362
C1367R	rs1346044
X-ray repair cross-complementing 2 (XRCC2; 7q36.1)
R188H	rs3218536
X-ray repair cross-complementing 3 (XRCC3; 14q32.3)
T241M	rs861539
Nucleotide excision repair
Excision repair cross-complementing 1 (ERCC1; 19q13.2)
IVS5 + 33A>C	rs3212961
Excision repair cross-complementing 2 (ERCC2; 19q13.3)
D312N	rs1799793
Excision repair cross-complementing 2 (ERCC2; 19q13.3)
K751Q	rs13181
Excision repair cross-complementing 4 (ERCC4; 16p13.3)
P379S	rs1799802
Excision repair cross-complementing 5 (ERCC5; 13q22)
D1104H	rs17655
RAD23 homolog B (RAD23B; 9q31.2)
A249V	rs1805329
Xeroderma pigmentosum C (XPC; 3p25)
K939Q	rs2228001
Base excision repair
Apurinic/apyrimidinic endonuclease (APEX1; 14q11.2)
D148E	rs3136820
Poly[ADP-ribose] polymerase (PARP; 1q41)
V762A	rs1136410
X-ray repair cross-complementing 1 (XRCC1; 19q13.2)
Q399R	rs25487
Direct damage reversal
O-6-methylguanine DNA methyltransferase (MGMT; 10q26)
I143V	rs2308321
K178R	rs2308327
L84F	rs12917

^*RAG1 is not considered a DNA repair gene but, rather, participates in the V(D)J recombination process with DNA repair genes active in NHEJ.