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. 2006 Jul 20;108(9):3161–3167. doi: 10.1182/blood-2005-01-026690

Table 2.

DNA repair pathways and genetic variants examined in relation to risk of non-Hodgkin lymphoma

Substitutions according to gene (gene symbol; location) RS no.
Nonhomologous end joining/V(D)J
    DNA ligase IV (LIG4; 13q33)
        T91 rs1805388
    Recombination-activating gene 1* (RAG1; 11p13)
        K820R rs2227973
    X-ray repair cross-complementing 4 (XRCC4; 5q13)
        N298S rs1805377
        S307 rs1056503
        A247S rs3734091
Homologous recombination repair
    Breast cancer 2, early onset (BRCA2; 13q12.3)
        N372H rs144848
        K1132 rs1801406
        S2414 rs1799955
        Ex27-336A>C rs15869
        N289H rs766173
        N991D rs1799944
    Nijmegen breakage syndrome (NBS1; 8q21)
        E185Q rs1805794
    Tumor protein p53 (TP53; 17p13.1)
        P72R rs1042522
    Werner syndrome (WRN; 8p12)
        V114I rs4987236
        M387I rs1800391
        L1074F rs2725362
        C1367R rs1346044
    X-ray repair cross-complementing 2 (XRCC2; 7q36.1)
        R188H rs3218536
    X-ray repair cross-complementing 3 (XRCC3; 14q32.3)
        T241M rs861539
Nucleotide excision repair
    Excision repair cross-complementing 1 (ERCC1; 19q13.2)
        IVS5 + 33A>C rs3212961
    Excision repair cross-complementing 2 (ERCC2; 19q13.3)
        D312N rs1799793
    Excision repair cross-complementing 2 (ERCC2; 19q13.3)
        K751Q rs13181
    Excision repair cross-complementing 4 (ERCC4; 16p13.3)
        P379S rs1799802
    Excision repair cross-complementing 5 (ERCC5; 13q22)
        D1104H rs17655
    RAD23 homolog B (RAD23B; 9q31.2)
        A249V rs1805329
    Xeroderma pigmentosum C (XPC; 3p25)
        K939Q rs2228001
Base excision repair
    Apurinic/apyrimidinic endonuclease (APEX1; 14q11.2)
        D148E rs3136820
    Poly[ADP-ribose] polymerase (PARP; 1q41)
        V762A rs1136410
    X-ray repair cross-complementing 1 (XRCC1; 19q13.2)
        Q399R rs25487
Direct damage reversal
    O-6-methylguanine DNA methyltransferase (MGMT; 10q26)
        I143V rs2308321
        K178R rs2308327
        L84F rs12917
*

RAG1 is not considered a DNA repair gene but, rather, participates in the V(D)J recombination process with DNA repair genes active in NHEJ.