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. 2006 Jul 20;108(9):3161–3167. doi: 10.1182/blood-2005-01-026690

Table 4.

Risk of NHL in relation to variants in DNA repair genes, by NHL case pathology

AII B-cell
Follicular
DLBCL
AII T-cell
DNA repair genes and variants Cases OR (95% CI) P trend Cases OR (95% CI) P trend Cases OR (95% CI) P trend Cases OR (95% CI) P trend Controls
Nonhomologous end joining/V(D)J genes
    LIG4 (T9I)
        CC 720 1.0 197 1.0 249 1.0 44 1.0 628
        CT 267 0.8 (0.7-1.0) 68 0.8 (0.6-1.1) 89 0.8 (0.6-1.1) 24 1.2 (0.7-2.0) 275
        TT 17 0.5 (0.3-1.0) .02 2 NC 6 0.6 (0.2-1.4) .07 1 NC 28
        CT or TT 284 0.8 (0.7-1.0) 70 0.7 (0.5-1.0) 95 0.8 (0.6-1.0) 25 1.2 (0.7-2.1) 303
    RAG1 (K820R)
        AA 737 1.0 190 1.0 263 1.0 52 1.0 722
        AG 230 1.3 (1.0-1.6) 59 1.3 (0.9-1.8) 75 1.1 (0.8-1.6) 16 1.2 (0.7-2.2) 185
        GG 32 2.8 (1.5-5.3) < .001 12 5.1 (2.3-11.7) < .001 5 1.3 (0.2-9.8) 1 NC 15
        AG or GG 262 1.4 (1.1-1.7) 71 1.5 (1.1-2.1) 80 1.2 (0.7-2.2) 17 1.2 (0.7-2.2) 200
Homologous recombination (HR) repair
    BRCA2 (N372H)
        AA 527 1.0 131 1.0 182 1.0 27 1.0 505
        AC 391 1.0 (0.8-1.2) 110 1.1 (0.8-1.5) 133 1.0 (0.8-1.3) 35 1.8 (1.1-3.1) 361
        CC 89 1.4 (1.0-2.1) 25 1.6 (1.0-2.6) 32 1.5 (1.0-2.4) 9 3.0 (1.3-6.8) .003 60
        CC or AC 480 1.1 (0.9-1.3) 135 1.2 (0.9-1.6) 165 1.1 (0.8-1.4) 44 2.0 (1.2-3.3) 421
    WRN (V114I)
        GG 591 1.0 164 1.0 184 1.0 44 1.0 553
        GA 78 0.8 (0.6-1.1) 22 0.8 (0.5-1.4) 23 0.7 (0.5-1.2) 6 0.8 (0.3-2.0) 91
        AA 5 0.5 (0.2-1.5) 1 NC 2 NC 0 NC 9
        GA or AA 83 0.8 (0.6-1.0) 23 0.7 (0.5-1.2) 25 0.7 (0.3-1.8) 6 0.7 (0.3-1.9) 100
    XRCC1 (R194W)
        CC 828 1.0 218 1.0 289 1.0 57 1.0 804
        CT 167 1.4 (1.1-1.9) .007 41 1.3 (0.9-2.0) 52 1.3 (0.9-1.8) 13 1.6 (0.8-3.0) 116
        TT 9 1.4 (0.5-3.9) 4 NC 4 NC 0 NC 7
        CT or TT 176 1.4 (1.1-1.8) 45 1.4 (1.0-2.1) 56 1.3 (0.9-1.8) 13 1.5 (0.8-2.8) 123

All analyses were adjusted for reference age (younger than 55 years, 55 to 64 years, 65 years or older), sex, race (White, African American, other), and study site. Participants with missing data are omitted. ICD-O codes for tumors included in each subgroup include the following: B-cell lymphoma: 9590, 9591, 9595, 9670-9673, 9675, 9676, 9678-9682, 9684, 9686-9688, 9690, 9691, 9695-9698, 9710, 9711, 9713, 9714; follicular lymphoma: 9676, 9690, 9691, 9695-9698; DLBCL: 9678-9682, 9684, 9688; T-cell lymphoma: 9700, 9702, 9705, 9706, 9708, 9709, 9713, 9714.

DLBCL indicates diffuse large B-cell lymphoma; OR, odds ratio; CI, confidence interval; NC, not calculated for cell sizes of 5 or fewer participants; and —, P > .05.