Table 2.

Discontinuations for patients receiving placebo or palifermin

		Palifermin
Cohort 1		Cohort 2	Cohort 3
	Placebo	40 μg/kg or 240 μg/kg total dose	60 μg/kg or 360 μg/kg total dose	60 μg/kg or 540 μg/kg total dose	60 μg/kg or 720 μg/kg total dose	All
Patients randomly assigned, no.	31	8	10	14	37	69
Patients discontinued and replaced, no. (%)	1 (3)	1 (13)	0	2 (14)	14 (38)	17 (25)
Patients with DLT who discontinued and were not replaced, no. (%)	1 (3)	0	0	2 (14)	1 (3)	3 (4)
Deaths of patients who received a transplant, no. (%)	5 (16)	2 (25)*	1 (10)	3 (21)	6 (17)*	12 (18)

^*One patient was replaced.