Table 4.
Effect of palifermin and methotrexate on oral mucositis severity
|
Maximum grade of oral mucositis, no. (%)
|
||||||
|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | P* | |
| Palifermin | .42 | |||||
| With methotrexate on day 11 | 4 (8) | 4 (8) | 8 (16) | 33 (67) | 0 (0) | |
| Without methotrexate on day 11 | 1 (6) | 3 (19) | 2 (13) | 10 (63) | 0 (0) | |
| Placebo | ||||||
| With methotrexate on day 11 | 0 (0) | 0 (0) | 7 (27) | 18 (69) | 1 (4) | |
| Without methotrexate on day 11 | 0 (0) | 0 (0) | 0 (0) | 4 (80) | 1 (20) | |
*
P value is comparison of grades 0 to 2 versus 3 to 4 in groups with or without day 11 methotrexate by palifermin versus placebo.