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Model for TCL1-tg effects on GC B cells that promote malignant transformation. Aberrantly elevated pEμ-B29-TCL1 expression in the GC enhances lymphocyte proliferation, increases resistance to FAS-induced cell death, and augments Aicda expression. Since GC B cells have reduced p53 expression,53 these tumorigenic features occur in a setting that is relatively permissive for usual (SHM, CSR) and abnormal genomic alterations, increasing the likelihood for GC B-cell lymphoma development.
