Table 1.
Flow cytometric analysis of IL-15-pretreated IL-15–/– B6 BM cell donors
|
BM cell donor/pretreatment, percent bone marrow cells (P)
|
|||
|---|---|---|---|
| Cell type | WT B6/PBS | IL-15-/- B6/PBS | IL-15-/- B6/rhIL-15 |
| Monocytes/granulocytes | 31.7 | 31.3 (.76) | 29.3 (.16) |
| Myeloid dendritic cells | 1.84 | 1.28 (.1) | 2.01 (.41) |
| Plasmacytoid dendritic cells | 2.72 | 2.26 (.009) | 2.63 (.74) |
| B lymphocytes | 22.3 | 25.9 (.12) | 18.6 (.04) |
| Natural killer cells | 1.47 | 0.16 (< .001) | 5.5 (< .001) |
Donor mice were pretreated with rhIL-15 or PBS as described in “Results.” Values represent mean percent of bone marrow cells that were CD11b+GR-1+ monocytes/granulocytes, CD11c+B220+ plasmacytoid dendritic cells, CD11c+B220- myeloid dendritic cells, CD11c-B220+ B cells, or NK1.1+CD3- NK cells. P values (in parentheses) were calculated using the Student t test for comparisons between wt B6 and IL-15- or control-treated IL-15-/- B6 donors. N = 10 donors per group.