Table 3.
Genes with unique expression profile in CLL
| Probe | Gene names | Fold change relative to MM | Fold change relative to WM | Description |
|---|---|---|---|---|
| Up-regulated in CLL compared with WM and MM | ||||
| 218704_at | FLJ20315 | 3.34 | 3.15 | Hypothetic protein FLJ20315 |
| 221010_s_at | SIRT5 | 3.44 | 2.86 | Sirtuin silent mating type information regulation 2 homolog 5 |
| 203072_at | MYO1E | 7.97 | 7.77 | Myosin 1E |
| 204155_s_at | KIAA0999 | 3.51 | 2.83 | ESTs |
| 204446_s_at | ALOX5 | 9.13 | 8.97 | Arachidonate 5-lipoxygenase |
| 208858_s_at | KIAA0747 | 4.95 | 4.93 | KIAA0747 protein |
| 214366_s_at | ALOX5 | 7.66 | 4.36 | Arachidonate 5-lipoxygenase |
| 208269_s_at | ADAM28 | 38.87 | 5.47 | A disintegrin and metalloproteinase domain 28 |
| 205389_s_at | ANK1 | 10.23 | 4.74 | Aankyrin 1, erythrocytic |
| 209670_at | TRAC | 13.03 | 7.38 | T-cell receptor α-chain (VDJC); human T-cell receptor active α-chain mRNA from JM-cell line, complete clusters of differentiation |
| 203685_at | BCL2 | 3.96 | 3.01 | B-cell CLL/lymphoma 2 |
| 214032_at | ZAP70 | 11.79 | 6.71 | ζ-chain (TCR)–associated protein kinase (70 kDa) |
| Down-regulated in CLL compared with WM and MM | ||||
| 222315_at | ESTs | 28.09 | 40 | ESTs |
| 202768_at | FOSB | 82.6 | 107.76 | FBJ murine osteosarcoma viral oncogene homolog B |
| 202708_s_at | H2BFQ | 4.88 | 3.07 | H2B histone family, member Q |
| 201830_s_at | NET1 | 19.4 | 23.7 | Neuroepithelial-cell transforming gene 1 |
| 201694_s_at | EGR1 | 8.62 | 6.41 | Early growth response 1 |
| 205780_at | BIK | 9.61 | 16.8 | BCL2-interacting killer (apoptosis-inducing) |
| 202733_at | P4HA2 | 3.32 | 3.1 | Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), α polypeptide II |
| 211143_x_at | NR4A1 | 3.95 | 3.19 | Nuclear receptor subfamily 4, group A, member 1 |
| 202095_s_at | BIRC5 | 4.78 | 6.41 | Baculoviral IAP repeat-containing 5 (survivin) |
| 209911_x_at | H2BFB | 4.88 | 2.94 | H2B histone family, member B |
| 204493_at | BID | 9.26 | 6.21 | BH3 interacting domain death agonist |
| 213182_x_at | CDKN1C | 4.33 | 6.94 | Vyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| 200670_at | XBP1 | 13.73 | 7.81 | X-box binding protein 1 |
| 203362_s_at | MAD2L1 | 3.34 | 3.53 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| 206665_s_at | BCL2L1 | 8.2 | 4.67 | BCL2-like 1 |
| 209642_at | BUB1 | 3.05 | 3.1 | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) |
| 202284_s_at | CDKN1A | 15.27 | 9 | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| 202870_s_at | CDC20 | 4.44 | 7.58 | CDC20-cell division cycle 20 homolog (Saccharomyces cerevisiae) |
| 210559_s_at | CDC2 | 3.36 | 4.08 | Homo sapiens mRNA for CDC2 δ T, complete clusters of differentiation |
| 211792_s_at | CDKN2C | 3.25 | 3.05 | Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
| 204641_at | NEK2 | 3.51 | 5.6 | NIMA (never in mitosis gene a)-related kinase 2 |
The top 10 up- and down-regulated genes plus other genes of interest are shown. For all probes, P < .001