Table 4.
Genes with unique expression profile in MM
| Probe | P | Gene name | Fold change relative to WM | Fold change relative to CLL | Description |
|---|---|---|---|---|---|
| Up-regulated in MM compared to CLL and WM | |||||
| 212253_x_at | < .001 | BPAG1 | 3.52 | 5.62 | Bullous pemphigoid antigen 1 (230/240 kDa) |
| 201064_s_at | < .001 | PABPC4 | 2.36 | 4.22 | Poly(A) binding protein, cytoplasmic 4 (inducible form) |
| 209968_s_at | < .001 | NCAM1 | 2.3 | 4.1 | Neural cell adhesion molecule 1 |
| 204271_s_at | < .001 | EDNRB | 17.6 | 12.5 | Endothelin receptor type B |
| 205309_at | < .001 | ASML3B | 3.41 | 4.67 | Acid sphingomyelinase-like phosphodiesterase |
| 204602_at | < .001 | DKK1 | 9.9 | 7.41 | Dickkopf homolog 1 (Xenopus laevis) |
| 202973_x_at | < .001 | KIAA0914 | 5.56 | 6.53 | KIAA0914 gene product |
| 203697_at | < .001 | Frizzled-related protein | 13.61 | 17.6 | FRZB; frizzled protein homolog |
| 202170_s_at | < .001 | AASDHPPT | 2.11 | 2.58 | Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase |
| 215059_at | < .001 | Homo sapiens mRNA: cDNA DKFZp564G112 (from clone DKFZp564G112) | 6.76 | 10.76 | Homo sapiens mRNA; cDNA DKFZp564G112 (from clone DKFZp564G112) |
| 210755_at | < .001 | HGF | 4.18 | 3.36 | Hepatocyte growth factor (hepapoietin A; scatter factor) |
| 209347_s_at | < .001 | MAF | 2.43 | 2.78 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) |
| 205071_x_at | < .001 | XRCC4 | 5.26 | 6.58 | X-ray repair complementing defective repair in Chinese hamster cells 4 |
| 206213_at | < .001 | WNT10B | 2.72 | 4.72 | Wingless-type MMTV integration site family, member 10B |
| 213693_s_at | < .001 | MUC1 | 2.22 | 2.61 | Mucin 1, transmembrane |
| 213425_at | < .001 | WNT5A | 3.33 | 4.55 | Wingless-type MMTV integration site family, member 5A |
| 203510_at | < .001 | MET | 4.27 | 4.9 | met proto-oncogene (hepatocyte growth factor receptor) |
| 212097_at | < .001 | CAV1 | 17.45 | 18.7 | Caveolin 1, caveolae protein, 22kD |
| 205945_at | < .001 | IL6R | 2.48 | 3.41 | Interleukin 6 receptor |
| 203987_at | < .001 | FZD6 | 2.87 | 4.97 | Frizzled homolog 6 (Drosophila) |
| 221609_s_at | < .001 | WNT6 | 2.26 | 2.73 | Wingless-type MMTV integration site family, member 6 |
| 203628_at | .018 | IGF1R | 2.33 | 2.85 | Insulin-like growth factor 1 receptor |
| Down-regulated in MM compared to CLL and WM | |||||
| 209269_s_at | < .001 | SYK | 30.17 | 26.91 | Spleen tyrosine kinase |
| 34210_at | < .001 | CD52 | 94.71 | 180.4 | CAMPATH-1 (human); mRNA sequence |
| 215537_x_at | < .001 | DDAH2 | 5.04 | 7.25 | Dimethylarginine dimethylaminohydrolase 2 |
| 204661_at | < .001 | CD52 | 62.91 | 115.2 | CDW52 antigen (CAMPATH-1 antigen) |
| 201721_s_at | < .001 | LAPTM5 | 9.51 | 16.39 | Lysosomal-associated multispanning membrane protein-5 |
| 203037_s_at | < .001 | KIAA0429 | 10.66 | KIAA0429 gene product | |
| 216237_s_at | < .001 | MCM5 | 5.2 | 8.1 | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (Saccharomyces cerevisiae) |
| 201954_at | < .001 | ARPC1B | 2.08 | 3.51 | Actin-related protein 2/3 complex, subunit 1 B (41 kDa) |
| 41220_at | < .001 | MSF | 3.8 | 7.59 | MLL septin-like fusion |
| 200934_at | < .001 | DEK | 21.98 | 28.82 | DEK oncogene (DNA binding) |
| 221969_at | < .001 | PAX5 | 6.58 | 12.04 | ESTs, Weakly similar to S57447 HPBRII-7 protein (Homo sapiens) |
| 206398_s_at | < .001 | CD19 | 23.57 | 45.66 | CD19 antigen |
| 205536_at | < .001 | VAV2 | 2.76 | 4.82 | vav 2 oncogene |
| 218806_s_at | < .001 | VAV3 | 2.86 | 5.21 | vav 3 oncogene |
| 202414_at | < .001 | ERCC5 | 2.03 | 3.01 | Excision repair cross-complementing rodent repair deficiency, complementation group 5 (Xeroderma pigmentosum) |
| 204054_at | < .001 | PTEN | 2.05 | 2.64 | Phosphatase and tensin homolog |
| 212888_at | < .001 | DICER1 | 2.32 | 2.88 | Homo sapiens clone 23938 mRNA sequence |
| 209193_at | < .001 | PIM1 | 3.18 | 3.06 | pim-1 oncogene |
| 201700_at | < .001 | CCND3 | 3.07 | 3.78 | Cyclin D3 |
| 205647_at | < .001 | RAD52 | 2.45 | 4.22 | RAD52 homolog (S cerevisiae) |
| 216299_s_at | .002 | XRCC3 | 3.1 | 3.17 | X-ray repair complementing defective repair in Chinese hamster cells 3 |
The top 10 up- and down-regulated genes plus other genes of interest are shown