Table 4.

Macrophage densities in the tissues of Csf1^op/Csf1^op; TgSGP/+ and Csf1^op/Csf1^op; TgSPP/+ mice

	Liver cells/mm2
Genotype	2-d-old mouse	3-mo-old mouse	Dermis cells/mm	Kidney cells/mm2	Bladder cells/mm2	Tendon cells/mm2	MMM cells/mm2
wt	744 ± 71	413 ± 10	245 ± 12	160 ± 17	161 ± 29	+ + + +	+ + + +
Csf1op/Csf1op	526 ± 47*	121 ± 18*	157 ± 25*	44 ± 11*	42 ± 4*	−	−
Csf1op/Csf1op; TgSGP4/+	457 ± 31*	248 ± 5*	246 ± 27	82 ± 9*	154 ± 20	+ +	+ +
Csf1op/Csf1op; TgSGP2/+	1251 ± 75†	464 ± 28	326 ± 53†	198 ± 13	184 ± 29	+ + + +	+ + +
Csf1op/Csf1op; TgSPP7/+	902 ± 79	309 ± 38*	229 ± 16	62 ± 14*	189 ± 23	+ + +	+ +
Csf1op/Csf1op; TgSPP2/+	1129 ± 72†	498 ± 75	297 ± 11†	163 ± 20	201 ± 19	+ + + +	+ + +

Mice used for dermis samples were 2 days old; those for kidney samples, 2 months old; those for bladder samples, 3 months old; tendon, 2 days old; and MMM, 6 weeks old. The antibody for all samples except MMM was F4/80; for MMM, it was MOMA-1.

Data (mean ± SD) are taken from 12 low-power fields of tissues from 2 mice of each genotype. Data are mean ± SD.

MMM indicates marginal metallophyllic macrophages; +, the degree of correction of MMM density in spleen and F4/80⁺ cell density in tendons of different transgenic lines in comparison with the wt; −, no correction.

^*P < .05; count lower than wt.

^†P < .05; count higher than wt.