Table 1.

Breadth of response for 13 expanded T-cell lines

Subject	CD4 count	Viral load, copies/mL	No. of CD4 epitopes, min/max	No. of CD8 epitopes, min/max
1	336	96	3/4	1/2
2	276	< 75	2	1
3	473	8 940	0	2
4	980	< 75	2/4	1
5	215	< 75	3/5	2/3
6	308	< 75	1/2	2/3
7	337	< 75	2/3	4/6
8	116	6 299	1	1-2
9	217	< 75	0	2
10	381	33 600	1	1-2
11	255	< 75	1/2	3/4
12	505	< 75	0	1/2
13	234	434	0	1
Total	NA	NA	16/24	22/31

For responses to adjacent OLPs, a minimal value (assuming that any 2 adjacent responses represent a single epitope) and a maximal value (assuming that adjacent responses represent discrete epitopes) were calculated. Limiting dilution analysis (not shown) identified discrete epitopes within adjacent OLPs recognized by some T-cell lines. There were no significant correlations between clinical parameters and breadth of expanded CD4⁺ or CD8⁺ T-cell responses (see “Patients, materials, and methods”).

NA indicates not applicable.