Table 2.
Patient BPI haplotypes in the discovery and validation cohorts and their associated risk of significant airflow decline after transplantation
|
tagSNPs
|
Haplotype frequencies
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype | 2738 | 7258 | 9083 | 10214 | 17016 | 23356 | 33065 | 36045 | Controls | Cases | Odds ratio (95% CI) | P values |
| Discovery cohort: all patients | ||||||||||||
| 1 | C | G | G | A | A | T | G | G | 0.251 | 0.183 | Referent | — |
| 2 | G | A | G | A | G | C | A | A | 0.137 | 0.123 | 1.22 (0.68-2.21) | .506 |
| 3 | C | A | G | A | G | C | A | A | 0.095 | 0.105 | 1.55 (0.84-2.84) | .157 |
| 4 | C | A | G | A | G | C | G | G | 0.081 | 0.083 | 1.27 (0.64-2.5) | .491 |
| 5 | C | G | C | A | A | C | G | G | 0.06 | 0.06 | 1.48 (0.67-3.28) | .333 |
| 6 | C | G | G | A | A | T | A | A | 0.054 | 0.102 | 3.1 (1.44-6.68) | .004 |
| 7 | C | G | C | A | A | T | G | G | 0.041 | 0.025 | 1.03 (0.35-3.02) | .956 |
| 8 | C | G | G | G | G | C | A | G | 0.041 | 0.042 | 1.22 (0.54-2.77) | .636 |
| 9 | C | G | G | G | G | C | A | A | 0.035 | 0.041 | 1.66 (0.64-4.19) | .281 |
| 10 | C | G | G | G | G | C | G | G | 0.026 | 0.031 | 2.31 (0.86-6.18) | .095 |
| 11 | C | A | G | A | G | C | A | G | 0.024 | 0.035 | 2.68 (0.9-8.0) | .077 |
| 12 | C | G | G | A | A | C | A | G | 0.019 | 0.006 | 0.27 (0.02-3.99) | .343 |
| 13 | C | G | G | A | A | C | A | A | 0.018 | 0.041 | 3.28 (1.07-10.07) | .038 |
| 14 | G | A | G | A | G | C | G | G | 0.016 | 0.034 | 3.0 (0.94-9.54) | .063 |
| Discovery cohort: white patients only | ||||||||||||
| 1 | C | G | G | A | A | T | G | G | 0.247 | 0.183 | Referent | — |
| 2 | G | A | G | A | G | C | A | A | 0.143 | 0.128 | 1.2 (0.65-2.2) | .568 |
| 3 | C | A | G | A | G | C | A | A | 0.098 | 0.108 | 1.67 (0.9-3.1) | .102 |
| 4 | C | A | G | A | G | C | G | G | 0.079 | 0.083 | 1.25 (0.61-2.55) | .536 |
| 5 | C | G | C | A | A | C | G | G | 0.066 | 0.071 | 1.61 (0.75-3.47) | .225 |
| 6 | C | G | G | A | A | T | A | A | 0.058 | 0.099 | 2.77 (1.27-6.07) | .011 |
| 7 | C | G | G | G | G | C | A | G | 0.047 | 0.044 | 1.15 (0.5-2.68) | .741 |
| 8 | C | G | C | A | A | T | G | G | 0.041 | 0.023 | 0.9 (0.29-2.82) | .861 |
| 9 | C | A | G | A | G | C | A | G | 0.029 | 0.036 | 1.72 (0.58-5.15) | .329 |
| 10 | C | G | G | G | G | C | A | A | 0.029 | 0.034 | 1.51 (0.5-4.54) | .462 |
| 11 | C | G | G | G | G | C | G | G | 0.026 | 0.028 | 2.14 (0.77-5.93) | .144 |
| 12 | C | G | G | A | A | C | A | G | 0.022 | 0.006 | 0.31 (0.02-4.24) | .382 |
| 13 | G | A | G | A | G | C | G | G | 0.021 | 0.047 | 3.07 (0.99-9.5) | .051 |
| 14 | C | G | G | A | A | C | A | A | 0.017 | 0.04 | 2.95 (0.89-9.85) | .078 |
| Validation cohort: all patients | ||||||||||||
| 1 | C | G | G | A | A | T | G | G | 0.238 | 0.133 | Referent | — |
| 2 | G | A | G | A | G | C | A | A | 0.12 | 0.191 | 2.83 (1.25-6.38) | .013 |
| 3 | C | A | G | A | G | C | G | G | 0.098 | 0.103 | 1.71 (0.57-5.14) | .343 |
| 4 | C | A | G | A | G | C | A | A | 0.088 | 0.037 | 1.0 (0.36-2.78) | .994 |
| 5 | C | G | G | A | A | T | A | A | 0.074 | 0.043 | 1.24 (0.34-4.5) | .742 |
| 6 | C | G | G | A | A | C | A | G | 0.046 | 0.041 | 1.41 (0.35-5.72) | .629 |
| 7 | C | G | G | G | G | C | A | A | 0.043 | 0.08 | 3.28 (1.14-9.44) | .027 |
| 8 | C | G | C | A | A | C | G | G | 0.036 | 0.064 | 1.82 (0.52-6.35) | .345 |
| 9 | C | G | C | A | A | T | G | G | 0.031 | 0.04 | 4.57 (1.16-17.95) | .03 |
| 10 | G | A | G | A | G | C | G | G | 0.025 | 0.036 | 2.29 (0.51-10.33) | .282 |
| 11 | C | G | G | G | G | C | A | G | 0.018 | 0.043 | 5.5 (1.24-24.38) | .025 |
For discovery cohort, n = 363; for white patients, n = 320; for validation cohort, n = 209. Haplotypes with a P ≤ .05 are shown in italics. All haplotypes were analyzed in multivariate models that included age at transplantation, pretransplantation FEV1, extent of GVHD and duration of follow-up as covariates.
CI indicates confidence interval; —, no P value for the group.