Table 4.
Patient LBP haplotypes in the discovery cohort and their associated risk of significant airflow decline after transplantation
|
tagSNPs
|
Haplotype frequencies
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype | 541 | 1598 | 1756 | 5584 | 7400 | 13506 | 17002 | 25276 | 28559 | 33158 | Controls | Cases | Odds ratio (95% CI) | P values |
| All patients | ||||||||||||||
| 1 | C | A | A | G | T | G | G | C | T | T | 0.325 | 0.265 | Referent | — |
| 2 | T | A | A | G | C | G | A | C | T | C | 0.224 | 0.259 | 1.44 (0.94-2.19) | .091 |
| 3 | C | A | A | G | C | G | A | C | T | C | 0.061 | 0.06 | 1.42 (0.72-2.79) | .312 |
| 4 | C | A | A | G | T | G | G | C | T | C | 0.051 | 0.05 | 1.27 (0.54-2.95) | .586 |
| 5 | C | T | G | G | C | G | A | C | T | C | 0.051 | 0.05 | 1.14 (0.55-2.37) | .724 |
| 6 | C | A | A | G | T | G | G | C | A | T | 0.037 | 0.04 | 1.38 (0.61-3.13) | .445 |
| 7 | C | A | A | G | T | G | A | C | T | C | 0.037 | 0.01 | 0.55 (0.19-1.54) | .254 |
| 8 | T | A | A | G | T | T | A | T | T | C | 0.035 | 0.077 | 2.8 (1.24-6.34) | .014 |
| 9 | C | T | A | G | T | G | A | C | T | C | 0.019 | 0.015 | 1.19 (0.27-5.3) | .824 |
| 10 | C | T | G | G | C | G | A | C | T | T | 0.008 | 0.028 | 4.8 (0.88-26.11) | .069 |
| White patients only | ||||||||||||||
| 1 | C | A | A | G | T | G | G | C | T | T | 0.337 | 0.274 | Referent | — |
| 2 | T | A | A | G | C | G | A | C | T | C | 0.225 | 0.263 | 1.38 (0.89-2.13) | .149 |
| 3 | C | A | A | G | C | G | A | C | T | C | 0.063 | 0.067 | 1.52 (0.77-3.02) | .23 |
| 4 | C | T | G | G | C | G | A | C | T | C | 0.05 | 0.051 | 1.08 (0.52-2.24) | .838 |
| 5 | C | A | A | G | T | G | G | C | T | C | 0.05 | 0.047 | 1.14 (0.46-2.88) | .775 |
| 6 | T | A | A | G | T | T | A | T | T | C | 0.04 | 0.083 | 2.62 (1.15-5.94) | .022 |
| 7 | C | A | A | G | T | G | A | C | T | C | 0.037 | 0.011 | 0.71 (0.26-1.95) | .509 |
| 8 | C | A | A | G | T | G | G | C | A | T | 0.036 | 0.038 | 1.24 (0.52-2.95) | .624 |
| Donors | ||||||||||||||
| 1 | C | A | A | G | T | G | G | C | T | T | 0.299 | 0.264 | Referent | — |
| 2 | T | A | A | G | C | G | A | C | T | C | 0.231 | 0.273 | 1.32 (0.87-1.99) | .194 |
| 3 | C | A | A | G | C | G | A | C | T | C | 0.07 | 0.047 | 0.76 (0.36-1.58) | .458 |
| 4 | C | A | A | G | T | G | G | C | T | C | 0.057 | 0.06 | 1.22 (0.61-2.46) | .571 |
| 5 | C | A | A | G | T | G | G | C | A | T | 0.046 | 0.042 | 1.05 (0.43-2.6) | .913 |
| 6 | C | A | A | G | T | G | A | C | T | C | 0.036 | 0 | 0.28 (0.06-1.33) | .11 |
| 7 | T | A | A | G | T | T | A | T | T | C | 0.035 | 0.065 | 2.2 (0.98-4.91) | .055 |
| 8 | C | T | G | G | C | G | A | C | T | C | 0.035 | 0.053 | 1.94 (0.82-4.59) | .129 |
| 9 | C | T | A | G | T | G | A | C | T | C | 0.024 | 0.018 | 0.94 (0.26-3.38) | .921 |
| 10 | T | A | G | A | C | G | G | C | T | C | 0.02 | 0.014 | 0.71 (0.18-2.88) | .635 |
For all patients, n = 363; for white patients, n = 320; for donors, n = 363. Haplotypes with a P ≤ .05 are shown in italics. All haplotypes were analyzed in multivariate models that included age at transplantation, pretransplantation; FEV1, extent of GVHD, and duration of follow-up as covariates.
— indicates no P value for the group.