Table 2.
Laboratory value associations with LDH in sickle cell disease
| Interpretation, variable | No. | r | P |
|---|---|---|---|
| Hemolysis | |||
| Hemoglobin | 212 | -0.56 | <.001 |
| Plasma hemoglobin | 170 | 0.45 | <.001 |
| Reticulocyte count | 202 | 0.43 | <.001 |
| Haptoglobin | 167 | -0.26 | .001 |
| Hemoglobin S | 212 | 0.36 | <.001 |
| Arginase | 119 | 0.35 | <.001 |
| Hemolysis plus hepatic | |||
| AST | 213 | 0.74 | <.001 |
| Indirect bilirubin | 213 | 0.55 | <.001 |
| Direct bilirubin | 213 | 0.55 | <.001 |
| Hepatic | |||
| ALT | 213 | 0.34 | <.001 |
| Hepatic plus bone | |||
| Alkaline phosphatase | 213 | 0.17 | .01 |
| Leukocytes | |||
| Leukocyte count | 212 | 0.34 | <.001 |
| Muscle | |||
| Creatine kinase | 212 | -0.14 | .04 |
| Renal | |||
| Creatinine | 213 | -0.10 | .1 |
| Endothelial activation | |||
| Soluble VCAM-1 | 161 | 0.38 | <.001 |
| Soluble ICAM-1 | 155 | 0.16 | .04 |
| Soluble E-selectin | 152 | 0.28 | .001 |
| Soluble P-selectin | 157 | 0.16 | .04 |
| Pulmonary | |||
| Oxygen saturation | 142 | -0.44 | <.001 |
Spearman correlation coefficients (r) and 2-tailed P values show degree of correlation of serum LDH level with various laboratory markers in a population of 213 patients with all forms of sickle cell disease.